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Am J Epidemiol (1998) 147:9329

Specifically, 41.7% of the surveyed patients reported a noticeable benefit in managing their systemic fatigue, brain fog, and post-exertional malaise, highlighting its role as a highly accessible and effective management tool

Lipoic acid has also been shown to improve nitric oxide (NO)-dependent vasodilation in aged rats by increasing PKB/Akt-dependent phosphorylation of endothelial NO synthase (eNOS) and eNOS-catalyzed NO production (47)

doi: 10.1111/j.1528-1167.2011.03235.x [PubMed] 22335736 Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y, Barsan W

This is a case report of multifocal oral pigmentation in gingiva and labial mucosa which was diagnosed to be melanotic macule with clinico-histopathologic evidence