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15(Suppl 3) S176-S180

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10.1016/j.abb.2011.10.012 35 IrrcherI.LjubicicV.HoodD

iPSC studies further show APOE4 upregulates sterol regulatory element-binding protein 2 to drive de novo cholesterol synthesis while disrupting cholesterol trafficking via lysosomal sequestration of free cholesterol (214)

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