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The median follow-up time was 984 d, and 21 patients were lost to follow-up

As a result of shear stress on the vasculature and skeletal muscle contractions during exercise, endothelial and myocellular calcium concentrations increase, leading to the activation of NOS in these cell types and enhanced NO production ( NO production via the NOS-independent pathway In the NOS-independent pathway, NO production is the result of the sequential reduction of nitrate to nitrite to NO

Effects of exercise intensity on cardiovascular fitness, total body composition, and visceral adiposity of obese adolescents

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