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Pekala, J

J Clin Psychopharmacol

doi: 10.1001/jamanetworkopen.2021.22844 37 LeverM.AtkinsonW.GeorgeP

10.5534/wjmh.17040 85 RoderfeldM
For instance, in preclinical models, long-term ketamine exposure increases the expression of GABA receptor subunits in the prefrontal cortex while simultaneously reducing glutamate receptor subunits, impairing synaptic signaling and cognitive function ( Ketamine also downregulates brain-derived neurotrophic factor, particularly in the hippocampus, exacerbating deficits in synaptic plasticity and cognitive functions

Mansour HH, El Kiki SM, Ibrahim AB, Omran MM