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Antibodies against LATS2-pS83 and PCNT are red and green in merged images, respectively, with DNA stained with DAPI (blue)

In contrast, FGF23 binds to the KlothoFGFR complex and activates the Mitogen-Activated Protein Kinase/Extracellular signal-Regulated Kinase 1 and 2 pathway, leading to the suppression of CYP27B1 and upregulation of the catabolic enzyme 24-hydroxylase (CYP24A1), which accelerates the degradation of 1,25(OH)D (13)

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Both human 5 -reductase-2 and 5 -reductase-1 genes have 5 exons and 4 introns, and encode a highly hydrophobic 254 and 259 amino acid protein with a molecular weight of approximately 28.4 and 29.5 kilodaltons, respectively