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Release of IL-1 into the medium and cleavage of IL-1 in the cell lysates were decreased 50% by HNE compared to control, but NLRP3 and pro-IL-1 protein levels did not change (Fig

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GenBank AA305120 EST176120 Colon carcinoma (Caco-2) cell line II Homo sapiens cDNA 5' end similar to similar to histone H2AZ, mRNA sequence

For normally distributed data a mixed linear model (MLM) was used, (as laid out by IBM in their SPSS Statistics guidelines, with mice IDs as subject variable and random effects, sex and APOE genotypes as factors, and age as a covariate