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ATGL expression and enzyme activity are both under complex regulation

More specifically, AX supplementation enhances the abundance of anaerobic genera such as Alistipes and Alloprevotella , both known to produce short-chain fatty acids (acetate, propionate, butyrate) and amino acidderived metabolites (e.g., pyruvate, isoleucine) that act as signaling molecules for mitochondrial activation and UCP1 transcription in adipose tissue [73,74]

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