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On the contrary, when tumor cells from Keap1 knockdown (kd) mice with increased Nrf2 activity were transplanted into nude mice, they showed increased tumorigenicity compared to cells derived from wild-type mice.29 Therefore, it is clear that NRF2 plays a dual role in lung cancer (Fig

Collectively, high levels of ROS play an important role in maintaining the undifferentiated state of MDSCs, which in turn mediates the immunosuppressive TME

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Escudo del sistema inmunolgico : El glutatin juega un papel clave en la proteccin y regulacin de nuestras clulas inmunes