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In the phase 3 EXPAND study, siponimod reduced the risk of 3-month confirmed disability progression by 21% compared with placebo and slowed the rate of brain volume loss over 12 and 24 months in people with SPMS [258]

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A notable example of a naturally occurring N- methylated peptide is cyclosporin A, a cyclic undecapeptide with immunosuppressive properties

For the fourth cohort analysis, the applicant identified 6,497 claims mapping to 173 MS-DRGs

Recombinant osteopontin improves neurological functional recovery and protects against apoptosis via pi3k/akt/gsk-3beta pathway following intracerebral hemorrhage