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Protein G (green) binding to an antibodys light chain (orange) and heavy chain (purple) (PDB: 1IGC)

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They are zinc-dependent exopeptidases that exhibit distinct substrate specificities: CCP1, 2, 3, 4, and 6 preferentially shorten -linked glutamate side chains, while CCP5 uniquely removes the branching -linked glutamate that initiates chain formation [24, 25, 33, 34] (Fig

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