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Several RNAi drugs, including aptamers like pegaptanib targeting protein targets, and micro interfering RNAs like givosiran and patisiran, as well as antisense oligonucleotides like golodirsen and inotersen that interfere directly with RNA targets, have received FDA approval for medical use (Yu et al., 2020)

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It suffers from bioavailability issues, and the CNS-targeting theory remains unvalidated for this specific compound

MgIG also downregulates the mRNA expression of TLR2, TLR4, and NF-B in the liver, thereby reducing the production of pro-inflammatory cytokines (e.g., TNF-, IL-6) and alleviating liver tissue inflammation and oxidative stress ( DG primarily alleviates amphotericin B-induced liver injury through dual mechanisms involving inhibition of oxidative stress and apoptosis ( 4.2.2 Hepatic injury caused by herbal medicines and their preparations GA effectively alleviates triptolide (TGT)-induced acute liver injury through multi-target and multi-pathway synergistic mechanisms

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Renal impairment appears to be reversible with cessation of drug administration