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Advances such as nucleoside modification and removal of double-stranded RNA contaminants have mitigated this issue, but even current mRNA-LNPs formulations can trigger reactogenic effects in a dose-dependent manner, and repeated dosing may be limited by immune reactions against delivery components (for instance, anti-polyethylene glycol (PEG) antibodies can form, since many LNPs incorporate PEGylated lipids) [2]

Lioudyno VI, Tsymbalova EA, Chernyavskaya EA, Scripchenko EY, Bisaga GN, Dmitriev AV, Abdurasulova IN

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Further studies showed that circ FOXP1 can increase the expression of SLC7A11 by directly sponging miR-520a-5p in lung cancer cells to promote lung cancer tumor growth [148]

In AD patients, these rates were found to be reduced