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Elevated NO levels are associated with the overexpression of nNOS and iNOS, and nNOS inhibition has been shown to exert neuroprotective effects and alleviate LID

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Incidentally these astrocytes did not possess ACE-2, known as a canonical SARS-CoV-2 gate into cells

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Furthermore, toll-like receptor (TLR)-mediated signals markedly increase Glut1 expression and glycolytic rates, which is detrimental to the stability and suppressive capacity of Treg cells [154]