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Although its etiology is still unclear, it has been established that environmental factors and susceptibility genes are involved in the pathogenesis of the disease

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[DOI] [PubMed] [Google Scholar] [153].Cassano P, Sciancalepore AG, Pesce V, Fluck M, Hoppeler H, Calvani M, Mosconi L, Cantatore P, Gadaleta MN

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Significant reductions in post-meal insulin concentrations and improved insulin sensitivity were also observed (Paradis 2011)

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+ channels, particularly the delayed rectifier K + channel family responsible for repolarization and afterhyperpolarization, together with inwardly rectifying K + currents and I h currents, regulate membrane excitability, firing adaptation, and rebound activity

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