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do not use DMSO or DMF to dissolve coelenterazines, because these solvents will oxidize the compounds

PPP did not compete with ATP but interfered with phosphorylation in the activation loop of the kinase domain, in which it specifically blocked phosphorylation of the tyrosine (Y) 1136 residue, while sparing the two others (Y1131 and Y1135)

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Conversely, existing renal impairment is unlikely to affect Linzess because of the drugs minimal absorption into the bloodstream