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found that SIAH1, an E3 ubiquitin protein ligase, ubiquitinates HMGCR and influences cholesterol metabolism by regulating key enzymes in cholesterol synthesis, thereby reducing sensitivity to the drug cisplatin ( 4.5 Fatty acid oxidation FAO utilizes acetyl-CoA subunits generated from fatty acids to produce nicotinamide adenine dinucleotide (NADH), acetyl-CoA, and adenosine triphosphate (ATP), supporting energy production, redox homeostasis, and biosynthetic reactions

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A search was conducted using databases of EMBASE, PubMed, Scopus, Cochrane Library, and ISI web of Science from inception to February 2019 without limitations in language

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