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Because longterm human studies are lacking, there are concerns about unknown immune, cardiovascular, or proliferative effects, and some experts warn that users may face unpredictable risks, especially with unsupervised use

C677T: G/G: typical function A/G: enzyme function decreased by ~40% A/A: enzyme function decreased by 7080% A1298C: T/T: typical function G/T: slightly decreased function G/G: enzyme function decreased by ~20% Are there other MTHFR variants that matter

PMID 20562698

Peroxynitrite as regulator of vascular prostanoid synthesis

Individuals with gastrointestinal conditions often require higher doses or injectable B12

A 2.5mg starting dose of tirzepatide requires 25 units at 10mg/mL