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This structural weakening not only impacts firmness but also contributes to increased skin transparency and bruising

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Adrenergic receptor ligands are known to modulate blood pressure and heart rate, while muscarinic antagonists produce a host of symptoms such as pupil dilation, urinary retention, constipation and dry mouth that are directly related to inhibition of the parasympathetic nervous system

As such, a recent paper described the concept of dynamic bias, which refers to changes in a biologic system due to alterations in physiologic and pathophysiological factors over time like aging, disease, or medications (Michel et al., 2014)

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The Yellow Card scheme: guidance for healthcare professionals