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To provide quantitative data on the possible role of HNE in oxidative genotoxicity, we applied an accurate HPLC-MS approach to the quantification of HNE adducts to DNA and of HNE conjugates to glutathione (HNE-GSH), the product of the major detoxification pathway of HNE in cells

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Background: Aging is an ubiquitous biological phenomena characterized by ever increasing susceptibility to diseases, toxic effects of xenobiotic and an ultimate genome-instability and diminished DNA-damage-repair capacity and []