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Lipid peroxidation Lipids play a crucial role in the regulation of cell death, with lipid-mediated oxidative stress and subsequent membrane damage being key factors leading to ferroptosis

Analysis of immune microenvironment components reveals that PC stage is associated with M2 macrophages, the marker gene of which is significantly correlated with GPX2

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Pharmacological or genetic inhibition of GSR significantly enhanced the execution of ferroptosis induced by sorafenib in HCC (Fig