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A consultation with an independent specialist will determine whether a single modality or a combined protocol represents the best treatment for your individual concerns

Initial Treatment/Dose Adjustment (Adults) Treatment with clomipramine should be initiated at a dosage of 25 mg daily and gradually increased, as tolerated, to approximately 100 mg during the first 2 weeks

Another oxidative stress biomarker, 8-hydroxy-2-deoxyguanosine (8-OHdG), reflects oxidative damage to DNA

Following OA induction, the rabbits were randomly divided into four groups with 8 subjects, each receiving a different weekly intra-articular treatment starting four weeks after the first collagenase injection

10.1007/s00432-018-2631-7 63 LiY.ChenH.XieX.YangB.WangX.ZhangJ.et al (2023)