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The N-terminal region of Nrf2, called the Neh2 domain, bridges the two DC domains at two separate binding sites, namely the ETGE and DLG motifs ( Figure 4B )

[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Oranje P., Gouka R., Burggraaff L., Vermeer M., Chalet C., Duchateau G., van der Pijl P., Geldof M., de Roo N., Clauwaert F., et al

Locke M, Ghazaly E, Freitas MO, Mitsinga M, Lattanzio L, Lo Nigro C, Nagano A, Wang J, Chelala C, Szlosarek P, et al

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Novel strategies towards reversal of cellular senescence Phenotypic and transcriptomic changes during cellular senescence have all been liked to changes at the epigenetic level