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The most frequent symptoms are: Developmental delays Anaemia Loss of appetite Chronic vomiting Weight loss Low brain volume Spasms/cramps Apathy Irritability In the most severe instance, vitamin B12 deficiency can lead to respiratory failures and coma (51)

GRAS safety assessment Stier H et al

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Kidney Int 92, 13561369

33 DelhayeJ.AlettiC.GlaizotO.ChristeP
