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Additionally, an amide derivative of NAC known as N-acetylcysteine amide (NACA) has been shown with higher BBB permeability and easier penetration to mitochondria and other cellular constituents compared to NAC resulting in higher central nervous system bioavailability and stronger therapeutic properties for oxidative stress and neuroinflammation following TBI

doi: 10.1074/jbc.274.22.15493 33 DhakshinamoorthyS.JaiswalA

Jaishy and Abel, 2016

Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system