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Tregs express more PD-1 than effector T cells in highly glycolytic malignancies, such as MYC-amplified tumors and liver cancers

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Conversely, a synthetic CPT1 activator, C75, significantly reduced the symptom of kidney fibrosis in an FA-induced murine model (Kang et al., 2015)

Specifically, through the high expression of glutamine transporters and key metabolic enzymes, tumor cells preferentially take up and utilize glutamine from the microenvironment, thereby establishing metabolic competition with immune cells such as T cells and NK cells

Aminoacidopathies (eg, isovaleric acidemia, propionic acidemia, methylmalonic acidemia, glutaric acidemia type I, 3-hydroxymethylglutaryl-CoA lyase deficiency) also contribute to the accumulation of acyl-CoA intermediates at the site of the metabolic block

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