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Spoke with my doctor who assured me this is an injection-site reaction, and encouraged me to get the second shot

The mechanistic studies revealed that NF-B inhibition occurs due to the binding of withaferin A to the thiol group of cysteine residues (Heyninck et al., 2014) (Gambhir et al., 2015)

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Navab M, Hama SY, Hough GP, Subbanagounder G, Reddy ST, Fogelman AM

Drugs Context 11:114 Niazi S, Gheisari M, Moravvej H, Doroodgar F, Niazi F (2022) Efficacy of cysteamine and methimazole in treating melasma: a comparative narrative review

17 These unique findings also highlighted a previously perceived, however poorly understood, interdependence between mucosal epithelium and overlying mucus layers, which collectively maintain the integrity of the mucosal barrier against luminal antigens (Figure 2)