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12 Although EMT endows CTCs with partial resistance to anoikis, the overexpression of TrkB, a neurotrophic tyrosine kinase receptor, also contributes to protection from apoptosis by activating the phosphatidylinositol 3-kinase (PI3K)AKT survival pathway

In the case of PD, better results might be obtained through the concurrent administration of L-DOPA with an iron chelator, as it helps to balance the dopaminergic pathway [179], which would otherwise be disrupted by iron deficiency [166, 167]

A 30-min permeability test for SF and EBA markers performed after the 24-h nanocarrier permeability assays confirmed that the integrity of the BBB models was preserved and the nanocarriers had no barrier damaging effect (Table S2)

Cinelli MA, Do HT, Miley GP, Silverman RB

Even minor bleeding inside the epidural space can complicate the procedure and increase discomfort afterward

Changes in the global burden of depression from 1990 to 2017: findings from the global burden of disease study
