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Biochemical analyses indicated that THPE2-F has promise as a therapeutic agent for DR, given its capacity to restore GSH levels and to regulate iron levels under hyperglycemic conditions in DR mice (147)

In: Barreiro C., Barredo J.-L., editors

Molecular mechanism and metabolic basis of ferroptosis Ferroptosis is a newly recognized type of iron-dependent cell death, characterized by iron overload and lipid peroxidation accumulation

This cytochrome metabolizes some endogenous compounds (e.g., polyunsaturated fatty acids, steroid hormones), small-molecule xenobiotics (e.g., ethanol, carbon tetrachloride), and a relatively small number of drugs for which it is mostly a complementary pathway of metabolism

The body redirects its energy and resources, leaving the gut exposed and vulnerable

Growth Horm IGF Res (2007) 17(4):31522.10.1016/j.ghir.2007.03.002 187 HattoriN