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The blood-brain barrier: Bottleneck in brain drug development
Senescent Chondrocyte Removal & Chondrogenic Potential Restoration (PMC, 2021) FOXO4-DRI Removes Replication-Stress Senescent Chondrocytes in ACI Research Model A study published in PMC investigated FOXO4-DRI in the context of autologous chondrocyte implantation (ACI) a procedure in which in vitro chondrocyte expansion generates a senescent cell burden that adversely affects cartilage formation quality and quantity

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Should these relationships hold then a metabolically stable blood-brain barrier penetrant small molecule that activates the HGF/c-Met system could prove highly efficacious in the treatment of PD
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