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Then, the WEN participated in the application of a control (n = 35) and high antioxidant diet (n = 37) for four months

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This is due to salicylic acids ability to dissolve the skins natural oils, which can disrupt the skin barrier and cause dryness in some individuals

Overall, there were no differences observed between dose groups, but statistical power was limited due to the small sample size in this study

Notably, L2HG-induced ferroptosis occurs independently of impaired cystine uptake, transsulfuration pathway activity, or increased GPX4-mediated GSH utilization, revealing a non-canonical ferroptosis mechanism driven by enhanced GSH catabolism