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When MTHFR enzyme function is deficient, B12 remains inactive

Abnormal iron metabolism and lipid peroxidation lead to an imbalance between the generation and degradation of reactive oxygen species (ROS), which can cause oxidative stress reactions (Pizzino et al., 2017)

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After the highest well-tolerated dose of everolimus (15 or 30 mg) in combination with paclitaxel was established, the size of this cohort would be expanded to 12 patients to obtain additional safety information on cumulative toxicity

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