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10.1093/toxsci/kfs296 65 LiuL.HuangH.LiY.ZhangR.WeiY.WuW

The intrinsic stability can be attributed to the following factors: (i) a basic Ig scaffold presenting a large number of charged and hydrophilic surface exposed residues compared to conventional antibody VH and VL domains found in murine antibodies

20-m cryosections were fixed for 10 min in 0.2% glutaraldehyde (Sigma Aldrich), washed three times in PBS for 5 min, and incubated overnight at 37 C with 1 mg/ml X-gal (Sigma Aldrich)

Nakahara T, Tsugawa S, Noda Y, Ueno F, Honda S, Kinjo M, et al

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The challenge now is understanding how they work for real patients, in real healthcare systems, and how evidence can be used to improve care across the entire patient journey