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[DOI] [PubMed] [Google Scholar] 108.Kaufmann Y., Spring P., Klimberg V.S

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The importance of these findings relates to the fact that in the pre-initiation and/or early stages of colon carcinogenesis the disruption of cellular defence mechanisms (consisting of a battery of detoxifying or antioxidant enzymes) would make cells more susceptible to DNA damage by both unwanted by-products of normal cellular metabolism (Fig