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Moreover, a US national study of 2,806 older women (50 years) found increased plasma concentration of methylmalonic acid the metabolic indicator of vitamin B 12 deficiency to be associated with increased risk of lumbar spine osteoporosis (115)

Headache is reported by approximately five to ten percent of patients, though this often improves with continued treatment

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J Immunol 186:18401848 Feng X, Zhang L, Acharya C, An G, Wen K, Qiu L et al (2017) Targeting CD38 suppresses induction and function of T regulatory cells to mitigate immunosuppression in multiple myeloma

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