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The conditions under which PknG is stimulated to phosphorylate or dephosphorylate GarA has not yet been investigated and it is not clear how the relationship between GarA, NAD + -GDH and PknG may impact nitrogen metabolism in the mycobacteria

126 The upregulation of IDH1 may represent a common metabolic adaptation for diminishing oxidative stress and supporting macromolecular synthesis, consequently promoting tumor growth and therapy resistance