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Takahashi N, Cho P, Selfors LM, Kuiken HJ, Kaul R, Fujiwara T, et al

Importantly, Cu selectively regulates the binding of HIF-1 to the HRE elements of target angiogenic genes by affecting the interaction between the transcription factor and the promoter region of the angiogenic genes [130, 131]

Future studies should focus on individualized supplementation based on PCOS phenotype, genetic background and nutrient-nutrient interactions ( Table 1 )

Chang HF, Huang WT, Chen HJ, Yang LL

These biomarkers could guide treatment decisions, helping clinicians select the most appropriate therapies for patients based on their individual senescence profiles.259 Developing Novel Delivery Systems: The efficacy of both senolytic and senomorphic therapies may be influenced by how these agents are delivered to target tissues