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In the SURPASS-2 trial, tirzepatide 15 mg was superior to semaglutide 1 mg for HbA1c reduction, with up to 46% of patients achieving near-normoglycemia (HbA1c below 5.7%)

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Glucagon-like peptide 1 treatment reverses vascular remodelling by downregulating matrix metalloproteinase 1 expression through inhibition of the ERK1/2/NF-B signalling pathway

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