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In the role of a dual-action medication, Mounjaro (tirzepatide) activates both GLP-1 and GIP receptors, enhancing insulin secretion while lowering glucagon levels

In light of all these studies, it should be emphasized that blood glucose should be monitored regularly when initiating or adjusting antidepressant therapy, and patients with diabetes should also be monitored for depressive symptoms due to the bidirectional relationship

Lifestyle factors amplify or buffer mood risk

In our future work, we will examine the comparative effectiveness of alternative treatment options for obesity in patients who discontinue semaglutide or tirzepatide, to help patients and their clinicians make informed decisions. In the obese group, the average body weight lost before discontinuation was 8.4%, with a regain rate of 0.5% one year later

While some benefits have been proven, most studies are short-term

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