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In HF with preserved ejection fraction and mildly reduced ejection fraction, semaglutide improved symptoms, physical function, natriuretic peptide levels, echocardiographic parameters, and HF hospitalizations, as shown in the STEP-HFpEF program and a pooled analysis of trials

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GLP-1 receptor agonists may be appropriate for patients with high blood pressure, though clinical monitoring and provider guidance are essential

Phase I clinical trial results for Amgens experimental weight-loss drug, MariTide, indicate it may provide longer-lasting effects compared to existing glucagon-like peptide-1 (GLP-1) treatments such as Novo Nordisks Wegovy and EliLillys Zepbound.