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glp 1 drugs pregnancy Millions of women of reproductive age are now taking GLP-1 medications like semaglutide and liraglutide for diabetes and weight management. A new systematic review in JACC: Advances asks an increasingly important question — GLP-1 use during early pregnancy
Description
Eight major RCTs of GLP-1RAs have investigated the cardiovascular outcomes, including the ELIXA trial of lixisenatide (250), the EXSCEL trial of exenatide ER (251), the LEARDER trial of liraglutide (252), the SUSTAIN-6 trial of subcutaneous semaglutide (253), the HARMONY trial of albiglutide (228), the REWIND trial of dulaglutide (254), the PIONEER trial of oral semaglutide (255), and the SELECT trial of subcutaneous semaglutide (199)

Accordingly, recent systematic reviews have provided substantial reassurance regarding the psychiatric safety profile of GLP-1RAs

[DOI] [PubMed] [Google Scholar] 84.Trujillo J.M., Nuffer W., Smith B.A
Frequently asked questions Which GLP-1 medication is most effective for weight loss

(2003) Improved biological activity of Gly2- and Ser2-substituted analogues of glucose-dependent insulinotrophic polypeptide

GLP-1 receptors are located in the brain, and GLP-1 is created in the brain in preproglucagon neurons