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GLP-1 is released by the intestines in response to eating, and it signals the pancreas to release insulin

For some patients, side effects are mild and manageable

doi: 10.1007/s13300-021-01078-y

Common side effects predominantly affect the gastrointestinal system and include: Nausea and vomiting (very common, especially during dose escalation) Diarrhoea or constipation Abdominal pain or discomfort Reduced appetite (intended therapeutic effect) Fatigue and dizziness These effects typically diminish as the body adjusts to the medication

Insert the needle through the center of the rubber stopper

Since the number of available contrasts for the non-hypothesized direction is too low, we will focus in the meta-analysis on the hypothesized direction for ghrelin and GLP-1