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Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, which reflect hepatocellular injury, typically decrease during GLP-1 therapy

This is actually one argument in favor of microdosing , where gastrointestinal effects are minimized while anti-inflammatory receptor activation may still occur

The Lancet Gastroenterology & Hepatology, 2024

Where there is concern, we have found that these risks can be effectively mitigated through a conservative treatment approach, phased injections over multiple sessions when using larger volumes, and more frequent follow-up

Clapp B, Wynn M, Martyn C, Foster C, ODell M, Tyroch A

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