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Keywords: GLP-1 receptor agonists, Neuroprotection, Synaptic plasticity, Central nervous system, Neurodegenerative diseases Graphical abstract Introduction GLP-1 receptor agonists (GLP-1RAs) are well-established treatments for type 2 diabetes mellitus (T2DM) and obesity, providing effective glycemic control, weight loss, and cardiovascular benefits [[1], [2], [3]]

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Retatrutide is only accessible in the UK through approved clinical trials

It is particularly intriguing that pharmacotherapies for AUD, e.g., naltrexone and topiramate, also reduce appetite and promote weight loss, a clinical observation consistent with the neurobiological overlap between AUD and obesity discussed before

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CVS Caremark removed Zepbound from these formulary types effective July 1, 2025: [2] Standard Control Formulary Most common employer formulary Advanced Control Formulary More restrictive formulary with lower premiums Value Formulary Cost-focused formulary used by smaller employers Class Action Lawsuits: What Patients Should Know In September 2025, two class action lawsuits were filed against CVS Caremark: [3][17] (Sept