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glp 1 exhaustion When fatigue shows up on GLP-1 therapy, I don't assume one cause. This is the framework I use clinically to guide evaluation. 📍Save this and discuss persistent symptoms with your healthcare What Should I Expect the
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doi: 10.1016/j.diabres.2020.108487

We now know that patients frequently discontinue GLP-1 therapy within months, negating long-term benefits, and also struggle to meet the requirements of lifestyle changes that are prescribed alongside the medication

General approach: If on Semaglutide 0.5 mg or less: Start tirzepatide at 2.5 mg If on Semaglutide 1.0 mg: Start tirzepatide at 5 mg If on Semaglutide 1.7-2.4 mg: Start tirzepatide at 5-7.5 mg Some providers start everyone at 2.5 mg regardless of previous dose to minimize side effects

doi: 10.1016/j.jacc.2024.04.022

Sodium glucose cotransporter-2 inhibitor protects against diabetic neuropathy and nephropathy in modestly controlled type 2 diabetes: follow-up study

The interface of depression and diabetes: treatment considerations
