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The distinction is critical

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Mller TD, Blher M, Tschp MH, et al

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This approach may result in less dramatic weight loss or glycemic improvement but can significantly improve tolerability and treatment adherence

Why Its Adaptive Remodeling, Not Muscle Wasting Every effective weight-loss intervention diet, exercise, surgery, or medication causes the body to lose both fat and lean tissue

Leptin is not essential for obesity-associated hypertension
