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Further details on the semaglutide model selection (including Akaike Information and Schwarz Bayesian Information Criteria) can be found in Additional file 2: Appendix Table S2

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In an aspect of the present invention, peptide having the amino acid sequence His- Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu- Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly has the formula His-Aib-Glu-Gly-Thr-Phe-Thr- Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg- Gly-Arg-Gly-Resin wherein the amino acids of the sequence are optionally protected with protecting group(s)

19 The significant reduction in WC with semaglutide compared to liraglutide suggests greater efficacy in mitigating these pathophysiological processes