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[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Monami M, Dicembrini I, Nardini C, Fiordelli I, Mannucci E

Similar dynamics are evident across other appetite-regulating peptide systems that warrant renewed evaluation under modern translational paradigms

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Although prospective studies specifically targeting PCOS + MASLD with pregnancy outcomes as the primary endpoint are currently lacking, a robust inference can be drawn based on the pathophysiological framework of MASLD and evidence from the general population: proactively identifying and reducing MASLD and ectopic fat load prior to pregnancy may be a key step in improving both periconception outcomes and long-term prognosis (68, 76)

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