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Rather than viewing complexity as an inherent liability, contemporary pharmacology increasingly recognizes that pleiotropic signaling can be therapeutically advantageous when appropriately modulated through dosing, bias, and patient stratification ( 7.1 Phoenixin: integrating metabolism, reproduction, and affect Phoenixin is a relatively recently described neuropeptide identified through bioinformatic analysis of conserved peptide sequences and expressed in both central and peripheral tissues

It is also under active research as a weight loss peptide in phase-3 studies, where it has led to over 20% weight loss within 72 weeks at the full dose of 15mg/weekly [49]

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When comparing the results of this study to those of previous GLP-1 RA-focused DCEs conducted in Japan, it is clear that the choice of therapies used to generate attribute levels has a significant impact on the relative importance of attributes