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2 Pathophysiology: molecular and cellular mechanisms of early-stage DR The pathogenesis of early-stage DR involves a cascade of metabolic, inflammatory, and vascular insults triggered by chronic hyperglycemia (Figure 1)

Tirzepatide works on two different hormonal receptors: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

The speed of results can differ from person to person, with some observing changes as soon as the first week of starting the Wegovy regimen

Keywords: Cardiovascular, Clinical relevance, Major adverse cardiovascular events, Number needed to treat, Semaglutide, Value Key Summary Points Introduction The World Health Organization (WHO) estimates that there are 1.6 billion adults living with overweight (defined as having a body mass index (BMI) of 2530 kg/m 2 ) and 890 million living with obesity (BMI 30 kg/m 2 ) [1]

Additionally, people who have had their thyroid glands removed (or who have gone through radioactive iodine treatment) may suffer adverse reactions from these procedures and will need to take thyroid medications for the rest of their lives