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239 Liraglutide mediated a significant decrease in CV mortality whereas exenatide reduced nonfatal stroke in diabetic patients

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Neuronal expression of GLP-1RAs is important for weight loss actions, signifying that these receptors mediate satiety and suppress food intake through appetite-suppressing circuits in the hypothalamus and other areas [30,35,36]

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Indeed, Australian guidelines recommend GLP-1RAs as an add-on option to metformin from the second-line setting (Fig

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